Jumat, 24 Februari 2012

Oxford Nanopore: A new meaning for Hole Genome Sequencing?

Two weeks ago I asked what Oxford Nanopore Technologies (ONT) was up to, and one week ago that they introduced their two new sequencing devices at the AGBT conference. This week, I review the press reactions in the seven days since ONT's announcement.

Share price development of leading sequencing companies on Friday, February 17th, when Oxford Nanopore introduced their new sequencers. Complete Genomics, Illumina, Pacific Biosciences, Life Technologies. For comparison, Nasdaq and Dow Jones.

ONT's $500-$900 tiny minION sequencer made it into several mainstream news outlets, especially in the UK, where the company is based. Coverage of ONT's announcement appeared in the Financial Times, the Guardian, and Nature. In the US, the ONT announcement made it into the New York Times.

The best technical summaries come from blogs, including Pathogens: Genes and Genomes, Core Genomics, and Omics! Omics!.

ONT is the first company to market nanopore sequencing, but it is unlikely to stay the only one for very long. Bio-IT World published information on rival nanopore sequencing company Genia Technologies, which plans to launch its device in 2013. Two other companies that are working on similar devices are Noblegen and Nabsys, promising a healthy dose of competition.

Kamis, 23 Februari 2012

It's All About ME . . . Or At Least It Should Be

A couple weeks ago I hit rock bottom. The stress level in my life had pressed so hard against my sanity, that I completely shut down, retreated from all my internet responsibilities and stopped writing. I was so overwhelmed that I even pulled back from friends and family. Sooo not like me.

I didn't sleep, but stayed in bed all day. I didn't eat. I cried for no reason. Depression, you say?  Yeah, just a bit.

It had been coming on for quite some time, but I'd somehow managed to hide it until our family dynamics changed and I found myself not only taking care of an almost-eighteen-year-old son with autism (with severe behaviors) and a 75-year-old mother-in-law (with advanced dementia). I could handle my son . . . barely, but to add another responsibility was just too much.

I cracked.

And in a desperate attempt to gain some control of my situation, I folded in on myself. NOT GOOD.

So here I was, having my own kind of pity party, not letting friends in, family pushed away, wallowing in the muck, when I began to reflect on my life. Okay, maybe the fact that I'm about to turn 50 had something to do with that too, but the point is, I discovered something. After 26 years of marriage, helping my husband run a restaurant for most of that, taking care of two boys with disabilities, losing one at 23 to a heart defect, and spending every moment taking care of everyone else . . .

I forgot to take care of ME. I forgot to LOVE me. And I never put me FIRST in anything.

How could I possibly care for others when I'd been neglected? How could I show love for those around me when I didn't even love myself?  And most of all, how was I going to put myself first, when I'd always been second or third or tenth?

The answer isn't easy and it certainly won't come all at once, but today I took the first step. I went to a doctor who specializes in Bariatrics (weight loss). They drew blood to check all the important stuff like cholesterol, blood sugar, thyroid, etc. They did an EKG to check my heart. You  name it, I was checked out from head to toe.

And then they got to the stuff that was a little hard to stomach. *gulp* I stepped on the scales. (Not revealing that number. Nope. No way) Then they figured my BMI (body mass index). EMBARRASSING. Took all my measurements. ICK!  And I sat through a 45 minute presentation on how I can become a healthier ME. Pure torture, because I found out what I'd been doing wrong all these years and why I'm so unhealthy.

Like, DUH!

There's a whole list of things I need to work on, some physical, others spiritual and very personal, but taking this first step, to be healthy, has made me smile. And I haven't done that for a long while.

My favorite quote from today's presentation?

"Nothing will change . . . unless there is change." (think about it)

How are you treating yourself these days?  Anything you can do to show yourself a little LOVE?

~ Christine

 

Day Trading Wins

Looks like day traders are the ones that are not getting bored to death in these markets. Things are pretty quiet. Up until a couple of days ago, the stock indices were mono-directional: UP. Now we are consolidating and the market will break one way or the other, eventually.


In the mean time, we make our living taking the middle out of the daily ranges. Not a lot of cream but more than enough milk.


This morning in London time, the DAX did it's thing. It hit the VAL of yesterday's higher distribution and failed there. It then sold off big time. As of the writing of this post, we've almost touched the VAL of the bottom distribution of 17 Feb.



Rabu, 22 Februari 2012

Wednesday Notes

Yesterday was quite a quietish day. We used to stand in the pit when it was quiet and say we'd never make money again. The market was dead. And then hell broke loose and we were in a manic period again. Markets go through quiet periods and the spring coils and then leaps out. In the mean time, there's money to be made but I just need to grind it out.

I bought the DAX on the open around 6908.0 and exited against the recent highs at about 6922.0. 14 points is 350 Euro per contract. The trend was identified as up. The market pulled back. I just bought the thrust up after that. Not too hard if you have the discipline to follow a trading plan. The Renko bars make it much clearer to see.

Today's trading was bits and pieces, Euro, ES and Light Crude. The transition is continuing as the world downsizes.


Looking into the Dark

Thinking of a blog post is never easy. In fact, until last week I had absolutely no idea what I would write about. You all may not know this about me but I'm intensely shy. I suffer from severe stage fright. It's ridiculous, I know. Still, it's a part of who I am and I worried that whatever I had to say would fail to meet the expectations of this wonderful group that I'm lucky to be a part of.

Fortunately something happened last week (and not the my-laptop-broke something) that provided inspiration.

I've been blogging on my own blog A New Kind of Ordinary for almost a year now. At some point during this time, my blog became a book blog. It was a natural transition given my profound and undying love for the written word. I've posted reviews on my blog regularly along with other content and never really thought my opinion was affecting anyone. I wrote mostly for me because I love to talk books.

Various PositionsHowever, last week I received not 1 but 4 pieces of hate mail. Now, I've deduced that these emails are related since, well, they all showed up in my inbox on the same day and they all made reference to a positive review of Various Positions that I had posted to Amazon that morning.

I'm a writer. I can take constructive criticism. I've conditioned myself to handle negative reviews. As a reader, I've realized that not everyone will hold the same opinion that I do about any particular book. Yet, these emails were hard to stomach. Mostly because they weren't constructive and they had little to do with my actual review. These ladies had no problem with how my review was written. They made it quite clear that the problem they had was with my promoting and praising a book that they deemed inappropriate for a young adult audience.

I've seen it before all over reviews on Amazon and Goodreads where people declare a book is not YA simply because it doesn't meet their standard for a young adult book. Various Positions has received a lot of comments like this. But really, who are we to judge? Can we really determine what is YA based upon our own personal experiences? If so, then Various Positions, in my opinion, is most definitely intended for a YA audience. Albeit a more mature YA audience but a YA audience nonetheless.

BreatheI always indicate in my reviews when books include themes that may be considered offensive or inappropriate, i.e. swearing, sex, drinking, violence, abuse. These women however didn't think this was enough. They kindly (*cough* *laugh*) demanded that I remove my review. They couldn't understand how any decent person, especially a 30 year old woman who no doubt had children of her own, could laud a YA novel filled with what they called perverse themes. They went so far as to accuse me of promoting underage sex. They claimed that people like me and sites like mine were the problem. That I lured in a young adult audience and presented them with pornographic material. They even insulted my as-yet-unreleased debut novel, Breathe, which addresses dark themes all its own.

Reading these emails, which I did multiple times, I concluded that these women must have not read the book in question. If they had, they would have seen my review for what it was: a positive assessment of a beautifully written work of art.

Since they hadn't, their argument was limited to name calling and bullying, expecting to shame me with their outrage.

After running the gamut of emotions, I finally figured out that I didn't care. My blog is family friendly. Yes, I write and review some books that are dark, edgy, or intended for a mature YA audience, but I always warn readers and allow them to make the decision to read or not to read on their own.

As a reader and a writer, I'm okay with sex and violence in YA literature. I'm okay with drinking and swearing and abuse. And no amount of bullying will change my position. Because somewhere out there someone is experiencing some or all of these things.

I don't condone these things but I won't denounce them either. It's life and some teenagers are going to drink and have sex whether or not they read certain books.

Yes, Various Positions tackles some edgy themes. The main character, Georgia, talks a lot about sex and fantasizes about her ballet instructor, and loses her virginity when she's drunk at a party to some boy she barely knows. But here's the thing, no one has the same young adult experience. Not everyone's teenage years are filled with rainbows and sunshine. Some of us have to deal with dark things too early.

Some of us lose our V-card in the back of a truck with some guy we're not even sure we like when we've had too much to drink. And while we can't remember saying no, we sure as hell didn't say yes. And we blame ourselves. We think that maybe if we'd been smarter, we wouldn't have been alone and drunk with a boy in the first place. If we hadn't worn that shirt or if we hadn't shared that first kiss. We feel alone and confused and we don't realize that we aren't the only ones experiencing these emotions.

Pieces of UsI will never reject dark themes. I will never relent to bullying. I will never change the stories I write regardless of the number of hate-filled emails I receive. I can't because you can't tell me that there's not a confused teenager that can't be helped by the issues addressed in books like Various Positions or books by Laurie Halse Anderson, Kelley York, Cheryl Rainfield, Ilsa J. Bick, or Margie Gelbwasser. You can't tell me that there won't be someone helped by my books.

I write for those kids.

The ones that remind me so much of me at that age. And I pray that what I, and other authors who look into the dark, have to say offers them a comfort the world oftentimes cannot.

--Melanie


----

Selasa, 21 Februari 2012

EuroSceptic

Well, the politicians have lived up to my expectations by squeezing Greece into an impossible situation. There is no way that Greece can continue to comply with the conditions it is being pushed into, IMO. Looks like the Euro politicians are buying time to get past elections and maybe to toughen up the Euro system. The way that this is going, it makes more sense for Greece to withdraw from the Euro. I can't see how else they can survive. They badly need to default to wipe out the debt, devalue their currency to make themselves more than competitive and to be able to feed the people who are left there. Greece is seeing the same thing as happened in Ireland - the young and able leaving in droves for other countries. Oz has one of the biggest Greek migrant communities and will benefit from that drain.

I'm still surprised that the stock markets are so strong. I guess it's money becoming worth less, day by day. But what will happen as earnings retreat when the Chinese and Indian markets slow down more? I'm still trying to find a spot to buy back the gold I stupidly sold around $880. I just couldn't resist that $500+ profit. Core holdings should stay core holdings unless there is something more compelling than being right in price direction.

We're working hard on beginning the daily pre-advice of my potential trades so that people can learn by following along. I'm shooting for a March start but there is some programming needed to take the load of manual labour. The tweeting of intraday trades is more of a pain as it's quite distracting for me, but I'm working on automating that too.

My Euro chart shows the story. Just grinding it out. Identify the trend and trade the pullbacks.


Senin, 20 Februari 2012

Another Highlander

There was only one. One trade that is. Market opened Gap up. If you didn't take the gap trade then there was only one good trade in the DAX in the London morning. Price hit the EMA support, and the uptrend resumed.